Second International Workshop on

Hybrid Systems and Biology

Taormina, Italy, September 2, 2013
at ECAL 2013


Workshop Program

09.00 - 09.10
Opening Session
09.10 - 10.25
Invited Talk: Alessandro Astolfi
Immune response enhancement via hybrid control

Session 1

10.25 - 10.45 Nicolas Mobilia, Alexandre Donzé, Jean Marc Moulis and Eric Fanchon.
Producing a Set of Models for the Iron Homeostasis Network
10.45 - 11.15 Coffee Break

Session 2

11.15 - 11.55 Ezio Bartocci, Luca Bortolussi, Laura Nenzi and Guido Sanguinetti.
On the Robustness of Temporal Properties for Stochastic Models
11.55 - 12.35 Lubos Brim, Jana Fabriková, Tomáš Vejpustek and David Šafránek.
Robustness Analysis for Value-Freezing Signal Temporal Logic
12.35 - 12.55 Ricardo G. Sanfelice and Qin Shu.
A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera
12.55 - 14.30 Lunch

Session 3

14.30 - 15.10 Tommaso Dreossi and Thao Dang.
Falsifying Oscillation Properties of Parametric Biological Models
15.10 -15.50 Vincent Noel, Sergey Vakulenko and Ovidiu Radulescu.
A hybrid mammalian cell cycle model
15.50 - 16.10 Oded Maler, Adam Halasz, Olivier Lebeltel and Ouri Maler.
Exploring the Dynamics of Mass Action Systems
16.10 - 16.45 Coffee Break

Session 4

16.45 - 17.25 Ye Chen, Adam Halasz and Jeremy Edwards.
VEGF Signaling with One Receptor Cluster
17.25 - 17.40
Closing Session

Invited Talk: Alessandro Astolfi

Immune response enhancement via hybrid control

This talk describes how the use of mathematical models of infectious diseases, and of hybrid control methods may result in the enhancement of the immune response. We mostly focus on the use of hybrid control to boost the immune reponse of HIV infected patients. To begin with we discuss in details the modelling assumptions and the effect of drug scheduling, formally and via simulations. We then develop a "therapeutic regime" based on "hybrid control" ideas and illustrate its effect on the immune system; and provide a hybrid systems interpretation for recent experimental studies on HIV prevention. The proposed ideas are finally exploited for malaria immunotherapy, in the treatment of myeloid leukaemia and of a general disease model.


Accepted Papers:

Online Proceedings:
Download Pdf:

Call for Papers

Systems biology aims at providing a system-level understanding of biological systems by unveiling their structure, dynamics and control methods. The intrinsic multi-scale nature of these systems, both in space, in organization levels, and in time, makes extremely difficult to model them in a uniform way, e.g., by means of differential equations or discrete stochastic processes. Furthermore, such models are often not easily amenable to formal analysis and their simulations at the organ or even the cell level are frequently impractical. Indeed, an important open problem is finding appropriate computational models that scale well for both simulation and formal analysis of biological processes. Hybrid modeling techniques, combining discrete and continuous processes, are gaining more and more attention in systems biology, and they have been applied to successfully capture the behavior of several biological complex systems, ranging from genetic networks, biochemical reactions, signaling pathways and cardiac tissues electrophysiology.

This workshop aims at collecting scientists working in the area of hybrid modeling applied to systems biology, in order to discuss about current achieved goals, current challenges and future possible developments.

Topics of interest include, but are not limited to:

We solicit the submission of unpublished results that address on both theoretical and applied aspects of hybrid modeling techniques in systems biology.
The proceedings will be published in the Electronic Proceedings in Theoretical Computer Science (EPTCS) series.

Paper submission
Full papers should be no more than 15 pages long, typesetted in the EPTCS-style.
Electronic submissions of abstracts and of full-length papers (in PDF format), can be done through the online submission system.


HSB 2013 will be co-located with ECAL 2013, 12th European Conference on Artificial Life, September 2-6 2013, Taormina, Italy.

The registration can be done via the ECAL 2013 web site.

Registration as Presenting Author: June 15, 2013

Early registration: June 15, 2013

Late registration: June 16 - September 6, 2013

On-Site registration: September 2-6, 2013

Important dates (tentative)

  June 14, 2013
Abstract submission deadline
  July 5, 2013 (initially 19 June)
Full paper submission deadline  
  July 31, 2013 (initially July 12)
Notification of paper acceptance
  August 10, 2013 (initially July 24)
Camera-ready of accepted papers

Invited Speaker

Program co-chairs

Program committee